If using a dedicated Twitter application isn't for you, that doesn't mean you have to miss out on a handful of useful keyboard shortcuts. Yes, that's right — twitter.com actually has keyboard shortcuts. Who knew?
The following are several keystrokes that you can use to make your Twitter experience a bit faster and more efficient:
N - Compose a new Tweet
R - Reply to a Tweet
F - Favorite a Tweet
T - Retweet a Tweet
M - Send a direct message
U - Mute a user (hides Tweets from your feed without unfollowing the user)
B - Block a user
The above shortcuts only apply to specific actions, but Twitter has a whole slew of others that are worth exploring. This includes shortcuts for navigating between tweets, quickly returning to the homepage, and even accessing your account settings.
A full list of shortcuts can be referenced at any time by pressing Shift + ? on your keyboard, displaying the following menu: